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Why are USP797 Cleanrooms Important?

USP797 has been a mandate that originated in the early 2000's.  The need arose after illnesses and in some cases, death, were caused due to microbial contamination of compounded sterile preparations.  The standards have gone through several changes since 2004 and will continue to evolve. The biggest challenge was noticed in the hospital sector.  Prior to USP797, hospital compounding was practiced but not in a cleanroom environment.   This left the hospital pharmacists in charge of building cleanroom environments to meet the USP797 mandate and ensuring the rooms met the regulations.  Inspections were conducted by State Boards of Pharmacy and JACHO.  This mandate will continue to make changes as challenges arise. 


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